Codon Design Online (CoDOn*) can be used to design a nucleotide sequence for improved expression of the desired protein within the target host organism. This method is useful for life science research, especially in the area of synthetic biology, where there is a need to achieve high expression of a foreign or artificial gene within a non-native host.

There are several methods of calculating the optimal output sequence. This web tool is an online implementation of the algorithm described in our previous publication (Chung BKS and Lee DY. Computational codon optimization of synthetic gene for protein expression. BMC Systems Biology 6:134). It has been further augmented to include additional optimization criteria, and multiple output sequences within pareto space. You may view an example of this pareto spatial distribution of results, by generating a new sample output dataset. Details on how this example was generated can be found in our guide.

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